Geropon T-77 is a high-performance anionic dispersant based on taurine-triazine technology, with an active ingredient content of 67%. Its unique molecular structure provides strong wetting ability, dispersion stability, and compatibility with various systems. In in vitrodiagnostic reagents, it is primarily used to stabilize colloidal particles, optimize reaction interfaces, and improve reagent homogeneity, particularly in detection systems with high solid content or complex sample matrices.

•High Dispersion Efficiency: Prevents aggregation of latex/colloidal gold particles through synergistic electrostatic repulsion and steric hindrance, ensuring signal stability (e.g., in immunoturbidimetric assays).

•Super-Wetting Ability: Rapidly reduces liquid-solid interfacial tension, promoting uniform penetration and spreading of reagents on hydrophobic surfaces (e.g., nitrocellulose membranes, plastic microplates).

•High Solid Content Compatibility: Tolerates high concentrations of particles or biomolecules (e.g., whole blood, mucus samples), reducing matrix interference and improving detection accuracy.

•Broad pH Stability: Maintains activity within pH 3–10, making it suitable for acidic or alkaline reaction systems (e.g., lysis buffers, wash buffers).

•Formulation Compatibility: Can be combined with anionic/non-ionic surfactants (e.g., AOS, Tween 20) to synergistically optimize dispersion and wetting performance.

•Latex-Enhanced Immunoturbidimetry: Pre-mixed in latex microparticle suspensions to prevent particle aggregation via electrostatic repulsion, enhancing the uniformity of turbidity signals (e.g., CRP detection).

•Colloidal Gold Marker Stabilization: Added to colloidal gold reconstitution solutions to reduce gold particle aggregation and improve color development consistency in lateral flow strips (e.g., hCG detection).

•High-Viscosity Sample Processing: Incorporated into mucus/whole blood diluents to reduce sample viscosity and promote the release of target analytes (e.g., respiratory pathogen testing).

•Microfluidic Chip Wetting Agent: Coated onto hydrophobic microchannels to optimize the flow performance of blood samples/reagents, preventing cell clogging or bubble retention.

•Solid Carrier Pretreatment: Used for nitrocellulose membrane/microplate pretreatment to enhance hydrophilicity and reduce non-specific adsorption.

Geropon® is a trademark of Solvay.

•Active Ingredient Conversion: The commercial product contains 67% active ingredient. During preparation, the actual quantity must be proportionally calculated (e.g., if 0.15% active ingredient is required, the actual product weight should be 0.15% / 0.67 ≈ 0.224%).

•Storage Conditions: Highly hygroscopic; after opening, store with desiccant protection.

•Compatibility Testing: Avoid direct mixing with cationic surfactants (e.g., CTAB) or high concentrations of polyvalent ions (e.g., Ca²⁺, Mg²⁺), as precipitation may occur.

•When used with enzymes, validate the activity retention rate (recommended concentration ≤0.1%).

•Latex Particle Aggregation: May result from insufficient concentration or excessively high ionic strength. Increase the concentration to 0.1%–0.2% or reduce the salt concentration in the buffer.

•Uneven Lateral Flow Speed: May be caused by insufficient wetting or improper membrane pretreatment. Optimize the concentration (0.05%–0.1%) or pre-coat with a Geropon T-77 solution.

•Increased Detection Background: May be due to inadequate washing and residual surfactant. Increase the number of wash cycles (e.g., 5–6 washes in ELISA).

•Reagent Turbidity: May result from reaction with cationic components. Switch to a neutral/anionic buffer system (e.g., Tris-HCl).