AccuSift provides high-performance fluoroquinolones competitive assay pairings, characterized by exceptional batch-to-batch consistency and optimized for IVD kit development (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.
Fluoroquinolones are a class of synthetic antibacterial agents belonging to the third and subsequent generations of quinolone drugs. They exert their effect by inhibiting bacterial DNA gyrase, thereby interfering with DNA replication. This class demonstrates broad-spectrum antibacterial activity, particularly against Gram-negative bacilli and some Gram-positive cocci. The introduction of a fluorine atom in 1979 with norfloxacin (third-generation) enhanced lipid solubility and antibacterial efficacy. Subsequently developed agents like ciprofloxacin and ofloxacin further optimized the antimicrobial spectrum and pharmacokinetic properties.These drugs exhibit good oral absorption and excellent tissue penetration, making them suitable for treating urinary tract, respiratory, and soft tissue infections. Common clinical varieties include norfloxacin, ciprofloxacin, and levofloxacin, while newer agents like moxifloxacin show enhanced activity against anaerobes and atypical pathogens. Potential adverse effects include central nervous system stimulation, photosensitivity, and irreversible peripheral neuropathy. Minors risk cartilage damage, and symptoms may worsen in patients with myasthenia gravis. Use with caution in pregnant or breastfeeding women and adolescents under 18 years old. Drug interactions, particularly with antacids, require attention for some specific agents.Performance Characteristics:
Sensitivity: ELISA IC50: 0.05 ppb; Colloidal Gold: 0.5 ppb
Pefloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Flumequine IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Norfloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Ofloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Enrofloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Lomefloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Levofloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Fleroxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Enoxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Ciprofloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Sarafloxacin IC50: 0.2 ppb; Colloidal Gold: 1–2 ppb
Difloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Marbofloxacin IC50: 0.2 ppb; Colloidal Gold: 1–2 ppb
Oxolinic Acid IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Nalidixic Acid IC50: 0.2 ppb; Colloidal Gold: 1–2 ppb
Pazufloxacin IC50: 0.2 ppb; Colloidal Gold: 1–2 ppb
Orbifloxacin IC50: 0.1 ppb; Colloidal Gold: 0.5–1 ppb
Source: Mouse Monoclonal Antibody
Recommended Pairing: (Coating) / (Labeling)
Storage: Long-term storage at ≤ –20°C; short-term storage at 2–8°C. Shipped on ice packs.
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