AccuSift provides high-performance broad-specificity antibody pairings for sulfonamides (SAs), characterized by exceptional batch-to-batch consistency and optimized for the development of In Vitro Diagnostic (IVD) kits across various platforms (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.Sulfonamides are folate synthesis inhibitors, consistently used due to their low cost and efficacy against pathogens causing urinary tract infections, trachoma, and other diseases. Their structure is similar to para-aminobenzoic acid (PABA), allowing them to competitively inhibit bacterial dihydropteroate synthase. This action prevents the synthesis of bacterial dihydrofolic acid, thereby inhibiting bacterial growth and reproduction. Sulfonamides are broad-spectrum antibacterial agents effective against both Gram-positive and Gram-negative bacteria. They selectively inhibit pathogens such as Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Chlamydia trachomatis, Chlamydia lymphogranuloma venereum, as well as Actinomyces, Pneumocystis, and Nocardia.Most systemically administered sulfonamides are readily absorbed orally and distribute widely into body tissues and various extracellular fluids including pleural fluid, peritoneal fluid, synovial fluid, aqueous humor, saliva, sweat, urine, and bile. They cross the blood-brain barrier into the cerebrospinal fluid, enter breast milk, and pass through the placental barrier.Performance Characteristics
•Sensitivity: ELISA IC50: 0.5 ppb; Colloidal Gold Visual Cut-off: 2 ppb
•Cross-Reactivity:
1.Sulfadimidine (Sulfamethazine, SM2): IC50: 1 ppb; Colloidal Gold: 2 ppb
2.Sulfamerazine (SM1): IC50: 1 ppb; Colloidal Gold: 4 ppb
3.Sulfamethoxydiazine (SMD): IC50: 2 ppb; Colloidal Gold: 3 ppb
4.Sulfamonomethoxine (SMM): IC50: 3 ppb; Colloidal Gold: 3 ppb
5.Phthalylsulfathiazole (PST): IC50: 2 ppb; Colloidal Gold: 3 ppb
6.Sulfisomidine (SM2'): IC50: 2 ppb; Colloidal Gold: 2 ppb
7.Sulfadiazine (SD): IC50: 2 ppb; Colloidal Gold: 10 ppb
8.Sulfachloropyridazine (SCP): IC50: 2 ppb; Colloidal Gold: 8 ppb
9.Sulfamonomethoxine (SMM/ESB3): IC50: 3 ppb; Colloidal Gold: 8 ppb
10.Sulfadimethoxine (SDM): IC50: 2 ppb; Colloidal Gold: 5 ppb
11.Sulfaquinoxaline (SQX): IC50: 2 ppb; Colloidal Gold: 8 ppb
12.Sulfamethizole (SMZ): IC50: 1 ppb; Colloidal Gold: 10 ppb
13.Sulfamethoxypyridazine (SMPZ): IC50: 5 ppb; Colloidal Gold: 10 ppb
14.Sulfathiazole (ST): IC50: 1 ppb; Colloidal Gold: 10 ppb
15.Sulfamoxole (SMO/SDMO): IC50: 1 ppb; Colloidal Gold: 90 ppb
16.Sulfisoxazole (SIZ): IC50: 1 ppb; Colloidal Gold: 50 ppb
17.Sulfapyridine (SP): IC50: 1 ppb; Colloidal Gold: 10 ppb
18.Sulfadimethoxine (SDM): IC50: 2 ppb; Colloidal Gold: 40 ppb
19.Sulfamethoxazole (SMZ): IC50: 1 ppb; Colloidal Gold: 50 ppb
20.Sulfaphenazole (SPP): Colloidal Gold: 300 ppb
21.Sulfabenzamide (SBA): Colloidal Gold: 200 ppb
22.Sulfacetamide (SAA): Colloidal Gold: 200 ppb
•Source: Mouse Monoclonal Antibody
•Purity: ≥ 90%
•Recommended Pairing: (Coating) / (Labeling)
•Storage: Long-term storage at ≤ -20°C; short-term storage at 2-8°C. Shipped on ice packs.
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