A1 β-Casein is a variant of β-casein found in mammalian milk. It is a confirmed casein-related allergen and a significant allergenic component in milk allergies. β-casein in mammalian milk is generally classified into two main variants: A1 and A2. A1 β-casein is what is commonly referred to as A1 casein.

The allergenicity of A1 casein stems from specific bioactive peptides generated during digestion. When digested, A1 casein releases Beta-Casomorphin-7 (BCM-7). BCM-7 acts as both an opioid peptide and a direct histamine-releasing agent. It can directly stimulate mast cells in the body to release histamine, triggering inflammation. Simultaneously, it can be absorbed into the bloodstream, inducing abnormal immune responses. This mechanism is associated with increased risks of various allergic and autoimmune diseases.

Regarding milk allergies, A1 casein is one of the clearly identified allergenic proteins. Indeed, most cases of casein allergy are actually allergies to the A1 variant.

AccuSift offers high-performance Anti-A1 β-Casein Antibodies specifically designed for competitive assay formats. Optimized for IVD kit development (including Lateral Flow Assays, Chemiluminescence, ELISA, and POCT), these antibodies feature high affinity, high specificity, and excellent batch-to-batch consistency for rapid and reliable detection.

Sensitivity: ELISA LOD: 1 ppb

Source: Mouse Monoclonal

Purity: ≥ 90%

Recommended Pair: (Coating) / (Labeling)

Storage & Shipping: Long-term storage at ≤ -20°C; short-term storage at 2-8°C. Shipped with ice packs.