This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Aliases :   GS; DP2; DP3; BTPS2; DP2.5; PPP1R46    

Entrez GeneID :   324    

Swissprot :   P25054    

WB Predicted band size :   311.6kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity :   Human    

Immunogen :   Purified recombinant fragment of human APC (AA: 2644-2843) expressed in E. Coli.    

ELISA    1/10000