ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).

Aliases    DOC1; APC10    

Entrez GeneID    10393    

Swissprot    Q9UM13    

WB Predicted band size    21.3kDa    

Host/Isotype    Mouse IgG1    

Species Reactivity    Human    

Immunogen    Purified recombinant fragment of human ANAPC10 (AA: 1-185) expressed in E. Coli.    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000