This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
Aliases： NS7; B-raf; BRAF1; RAFB1; B-RAF1
Entrez GeneID： 673
Swissprot ： P15056
WB Predicted band size ： 84.4kda
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human, Mouse, Monkey
Immunogen ： Purified recombinant fragment of human BRAF (AA: 299-447) expressed in HEK293-6e.
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