This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome.

Aliases:   ACTSA;α-Smooth Muscle Actin;Alpha-actin-2;Alpha actin 2    

Entrez GeneID:   59    

Swissprot:    P62736      

WB Predicted band size:    42kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human, Mouse    

Immunogen:    Purified recombinant fragment of human ACTA2 (AA: E(ace)EEDSTALVCDNGSGc) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000