AccuSift provides high‑performance α‑amanitin competitive assay pairings, characterized by exceptional batch‑to‑batch consistency and optimized for IVD kit development (Lateral Flow, Chemiluminescence, ELISA, POCT). These pairings offer high affinity and specificity, facilitating rapid detection.α‑Amanitin is a bicyclic octapeptide toxin isolated from highly poisonous mushrooms (such as Amanita phalloidesand A. verna). It is chemically stable and heat‑resistant; a dose of 0.1 mg/kg can be lethal to adults. Its toxicity results from specific binding to eukaryotic RNA polymerase Ⅱ, inhibiting mRNA synthesis and leading to hepatic and renal cell necrosis. The latent period is 6–24 hours, with clinical stages of gastroenteritis, false recovery, and fulminant hepatic failure. Without treatment, mortality reaches 50%–90%.Performance Characteristics:
Sensitivity: ELISA IC50: 1 ppb
Cross‑Reactivity: β‑Amanitin 1 ppb
Source: Mouse Monoclonal Antibody
Recommended Pairing: (Coating) / (Labeling)
Storage: Long‑term storage at ≤ –20°C; short‑term storage at 2–8°C. Shipped on ice packs.
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