This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Aliases:    FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1    

Entrez GeneID:    4436    

Swissprot :   P43246      

WB Predicted band size :   104.7kDa    

Host/Isotype:    Mouse IgG2b    

Species Reactivity :   Human    

Immunogen :   Purified recombinant fragment of human MSH2 (AA: 442-586) expressed in E. Coli.    

WB    1/500 - 1/2000 

IF/ICC    1/200 - 1/1000      

FCM    1/200 - 1/400    

ELISA    1/10000