This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Aliases：    FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1; MMRCS2    

Entrez GeneID：    4436    

Swissprot ：   P43246      

WB Predicted band size：    104.7kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human, Mouse, Rat, Monkey    

Immunogen ：   Purified recombinant fragment of human MSH2 (AA: (2-151) expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000