E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Aliases ： UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1；E-cadherin；E cadherin
Entrez GeneID ： 999
Swissprot： P12830
WB Predicted band size ： 135kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse,Monkey
Immunogen ： Purified recombinant fragment of human CDH1 expressed in E. Coli.
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