This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
Aliases ： HPT1; CDH16; HPT-1
Entrez GeneID： 1015
Swissprot ： Q12864
WB Predicted band size ： 92.2kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human CDH17 (AA: extra(600-707)) expressed in E. Coli.
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