This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Aliases : HP1; HP1A; HEL25
Entrez GeneID : 23468
Swissprot : P45973
WB Predicted band size : 22.2kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human,Mouse
Immunogen : Purified recombinant fragment of human CBX5 (AA:1-191) expressed in E. Coli.
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