This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Aliases : BCLW; BCL-W; PPP1R51; BCL2-L-2
Entrez GeneID : 599
Swissprot : Q92843
WB Predicted band size : 20.7kDa
Host/Isotype: Mouse IgG2a
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human BCL2L2 (AA: 6-118) expressed in E. Coli.
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