The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.

Aliases:    FDH; FTHFD; 10-fTHF; 10-FTHFDH    

Entrez GeneID:    10840    

Swissprot:    O75891    

WB Predicted band size :   98.8kDa    

Host/Isotype:    Mouse IgG1       

Species Reactivity:    Human, Rat    

Immunogen:    Purified recombinant fragment of human ALDH1L1 (AA: 10-222) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000