SRC: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian). This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Aliases:    ASV; SRC1; c-SRC; p60-Src    

Entrez GeneID:    6714    

Swissprot:    P12931    

Host/Isotype:    Mouse IgG2a    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of SRC (aa10-193) expressed in E. Coli.    

WB    1/500 - 1/2000    

ELISA    1/10000