This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Aliases： TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
Entrez GeneID： 6402
Swissprot： P14151
WB Predicted band size： 42.2kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human SELL (AA: 83-186) expressed in E. Coli.
WeChat
