Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main effector of PDK1.

Aliases：    PDK1; PDPK2; PDPK2P; PRO0461    

Entrez GeneID：    5170    

Swissprot：    O15530    

WB Predicted band size：    63.2kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human,Mouse,Monkey,Rat    

Immunogen：    Purified recombinant fragment of human PDPK1 (AA: 457-556) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/50 - 1/200    

FCM    1/200 - 1/400    

ELISA    1/10000