The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Aliases:    PDE1B1; PDES1B    

Entrez GeneID :   5153    

Swissprot :   Q01064    

WB Predicted band size:    61.4kDa    

Host/Isotype :   Mouse IgG1    

Species Reactivity:    Human,Rat    

Immunogen :   Purified recombinant fragment of human PDE1B (AA: 370-536) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000