Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]

Aliases :   NFL; NF-L; NF68; CMT1F; CMT2E; CMTDIG; PPP1R110    

Entrez GeneID:    4747    

Swissprot:    P07196    

WB Predicted band size:    61.5kDa    

Host/Isotype:   Mouse IgG1    

Species Reactivity:    Human,Mouse,Rat,Rabbit    

Immunogen:    Purified recombinant fragment of human NEFL (AA: 1-200) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/100 - 1/500    

FCM    1/200 - 1/400    

ELISA    1/10000