This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Aliases：    DMX; hdm2; ACTFS    

Entrez GeneID：    4193    

Swissprot ：   Q00987    

WB Predicted band size ：   55.2kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity ：   Human    

Immunogen ：   Synthesized peptide of human MDM2 (AA: cSRPSTSSRRRAISE).    

FCM    1/200 - 1/400    

ELISA    1/10000