This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Aliases：    HDMX; LSKB; hdm2; ACTFS    

Entrez GeneID：    4193    

Swissprot：    Q00987     

WB Predicted band size：    55.2kDa    

Host/Isotype：    Mouse IgG2b    

Species Reactivity ：   Human    

Immunogen ：   Purified recombinant fragment of human MDM2 (AA: 26-169) expressed in E. Coli.    

IHC    1/200-1/1000    

FCM    1/200-1/400    

ELISA    1/10000