The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Aliases： JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
Entrez GeneID： 5602
Swissprot ： P53779
WB Predicted band size ： 52.6kDa
Host/Isotype： Mouse IgG2a
Species Reactivity： Human,Rat
Immunogen： Purified recombinant fragment of human MAPK10 (AA: 180-329) expressed in E. Coli.
WeChat
