MAPK10: mitogen-activated protein kinase 10, also known as JNK3, JNK3A, PRKM10, p54bSAPK. Entrez Protein NP_002744. It is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Aliases： JNK3; JNK3A; PRKM10; p54bSAPK
Entrez GeneID： 5602
Swissprot： P53779
WB Predicted band size ： 53kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse
Immunogen： Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.
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