MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Aliases ：   HGK; NIK    

Entrez GeneID：    9448    

Swissprot ：   O95819    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human,Mouse    

Immunogen：    Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/50 - 1/200    

FCM    1/200 - 1/400    

ELISA    1/10000