MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Aliases： HGK; NIK
Entrez GeneID： 9448
Swissprot ： O95819
Host/Isotype ： Mouse IgG1
Species Reactivity ： Human,Mouse
Immunogen： Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli.
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