This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Aliases：    IGFR; CD221; IGFIR; JTK13    

Entrez GeneID：    3480    

Swissprot：    P08069    

WB Predicted band size：    154.8kDa    

Host/Isotype：   Mouse IgG2a    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human IGF1R (AA: extra(741-935)) expressed in E. Coli.    

WB    1/500 - 1/2000    

FCM    1/200 - 1/400    

ELISA    1/10000