The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines.
Aliases: HKI; HXK1; HK1-ta; HK1-tb; HK1-tc; HK1
Entrez GeneID : 3098
Swissprot: P19367
WB Predicted band size : 102kDa
Host/Isotype : Mouse IgG1
Species Reactivity: Human,Mouse,Rat
Immunogen: Purified recombinant fragment of human HK1 expressed in E. Coli.
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