Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Aliases：    HD1; RPD3; KDAC1; GON-10; RPD3L1    

Entrez GeneID：    3065    

Swissprot：   Q13547    

WB Predicted band size ：   55.1kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity：    Human, Mouse    

Immunogen ：   Purified recombinant fragment of human HDAC1 (AA: 321-482) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000