This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Aliases： ER; ESR; Era; ESRA; ESTRR; NR3A1
Entrez GeneID： 2099
Swissprot ： P03372
WB Predicted band size： 66.2kDa
Host/Isotype ： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,Rabbit
Immunogen ： Purified recombinant fragment of human ESR1 (AA: 2-185) expressed in E. Coli.
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