This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

Aliases：    BWS; WBS; p57; BWCR; KIP2; p57Kip2    

Entrez GeneID：    1028    

Swissprot：    P49918       

WB Predicted band size：    32.2kDa    

Host/Isotype：    Mouse IgG1    

Species Reactivity：    Human    

Immunogen：    Purified recombinant fragment of human CDKN1C expressed in E. Coli.    

IHC    1/200-1/1000    

FCM    1/200-1/400    

ELISA    1/10000