The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
Aliases ： MLA1; ME491; LAMP-3; OMA81H; TSPAN30
Entrez GeneID ： 967
Swissprot ： P08962
WB Predicted band size： 25.6kDa
Host/Isotype ： Mouse IgG2a
Species Reactivity ： Human
Immunogen ： Purified recombinant fragment of human CD63 (AA: extra 103-203) expressed in E. Coli.
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