This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
Aliases ： INSR; HHF5
Entrez GeneID： 3643
Swissprot ： P06213
WB Predicted band size ： 156kDa
Host/Isotype ： Mouse IgG2a
Species Reactivity： Human
Immunogen： Purified recombinant fragment of human CD220 (AA: extra 413-624) expressed in E. Coli.
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