CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Aliases ：   LAD; MF17; LCAMB; LFA-1; ITGB2    

Entrez GeneID：    3689    

Swissprot：    P05107    

WB Predicted band size：    85kDa    

Host/Isotype：    Mouse IgG2b      

Species Reactivity：    Human,Mouse    

Immunogen ：   Purified recombinant fragment of CD18 expressed in E. Coli.    

IF/ICC    1/200 - 1/1000    

ELISA    1/10000