The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Aliases： IL6ST; GP130; CDW130; IL-6RB
Entrez GeneID： 3572
Swissprot ： P40189
WB Predicted band size ： 103.5kDa
Host/Isotype： Mouse IgG1
Species Reactivity ： Human,Monkey
Immunogen ： Purified recombinant fragment of human CD130 (AA: extra 73-231) expressed in E. Coli.
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