This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
Aliases ： IL4R; IL4RA; IL-4RA
Entrez GeneID： 3566
Swissprot ： P24394
WB Predicted band size： 89.7kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity ： Human
Immunogen： Purified recombinant fragment of human CD124 (AA: 26-232) expressed in E. Coli.
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