This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Aliases :   M33; CDCA6; SRXY5    

Entrez GeneID:    84733    

Swissprot:    Q14781    

WB Predicted band size:    56kDa    

Host/Isotype :   Mouse IgG1   

Species Reactivity :   Human,Mouse,Rat,Rabbit,Monkey    

Immunogen:    Purified recombinant fragment of human CBX2 (AA: 402-525) expressed in E. Coli.    

WB    1/500 - 1/2000    

IHC    1/200 - 1/1000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000