This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Aliases：   CDM; HCAD; LCAD; H-CAD; L-CAD; NAG22    

Entrez GeneID ：   800    

Swissprot：    Q05682       

WB Predicted band size：    93.2kDa    

Host/Isotype ：   Mouse IgG1    

Species Reactivity ：   Human    

Immunogen：    Purified recombinant fragment of human CALD1 (AA: 26-207) expressed in E. Coli.    

IHC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000