This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.

Aliases：    BUB1A; BUB1L; Hbub1    

Entrez GeneID：    699    

Swissprot：    O43683    

WB Predicted band size：    122.4kDa    

Host/Isotype ：   Mouse IgG1      

Species Reactivity：    Human    

Immunogen ：   Purified recombinant fragment of human BUB1 (AA: 1-130) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000