This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
Aliases： FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1
Entrez GeneID： 6046
Swissprot ： P25440
WB Predicted band size ： 88kDa
Host/Isotype ： Mouse IgG2b
Species Reactivity ： Human,Rat
Immunogen： Purified recombinant fragment of human BRD2 (AA: 227-364) expressed in E. Coli.
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