This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Aliases： AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; MGC111051
Entrez GeneID ： 29760
Swissprot： Q8WV28
WB Predicted band size ： 68kDa
Host/Isotype： Mouse IgG1
Species Reactivity： Human,Mouse,Rat,,Monkey
Immunogen ： Purified recombinant fragment of human BLNK expressed in E. Coli.
WeChat
