This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Aliases ： AMPH2; AMPHL; SH3P9
Entrez GeneID： 274
Swissprot： O00499
WB Predicted band size： 64.7kDa
Host/Isotype： Mouse IgG2b
Species Reactivity： Human,Mouse
Immunogen： Purified recombinant fragment of human BIN1 (AA: 189-398) expressed in E. Coli.
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