The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Aliases : BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
Entrez GeneID: 604
Swissprot: P41182
WB Predicted band size : 78.8KDa
Host/Isotype : Mouse IgG1
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human BCL6 (AA: 507-706) expressed in E. Coli.
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