Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Aliases: CLAP; Me10; CIPER; c-E10; CARMEN
Entrez GeneID : 8915
Swissprot : O95999
WB Predicted band size: 26kDa
Host/Isotype: Mouse IgG1
Species Reactivity : Human,Mouse
Immunogen : Purified recombinant fragment of human BCL-10 expressed in E. Coli.
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