The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.

Aliases:    HAP; BAG-1; RAP46    

Entrez GeneID:    573    

Swissprot :   Q99933       

WB Predicted band size :   38.8kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity:    Human    

Immunogen:    Purified recombinant fragment of human BAG1 (AA: 219-346) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000