Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Aliases :   ASP2; BACE; HSPC104    

Entrez GeneID:    23621    

Swissprot :   P56817        

WB Predicted band size:    55.7kDa    

Host/Isotype:    Mouse IgG1    

Species Reactivity :   Human,Mouse,Rat    

Immunogen :   Purified recombinant fragment of human BACE1 (AA: 112-324) expressed in E. Coli.    

WB    1/500 - 1/2000    

IF/ICC    1/200 - 1/1000    

FCM    1/200 - 1/400    

ELISA    1/10000