This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development.

Aliases:  16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1    

Entrez GeneID:  537    

Swissprot:  Q15904    

WB Predicted band size:  52kDa    

Host/Isotype:  Mouse IgG1      

Species Reactivity:  Human, Mouse    

Immunogen:  Purified recombinant fragment of human ATP6AP1 (AA: 51-151) expressed in E. Coli.    

FCM    1/200 - 1/400    

ELISA    1/10000