Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Aliases : APG4B; AUTL1
Entrez GeneID : 23192
Swissprot : Q9Y4P1
WB Predicted band size : 44.3kDa
Host/Isotype : Mouse IgG1
Species Reactivity : Human
Immunogen : Purified recombinant fragment of human ATG4B (AA: 1-221) expressed in E. Coli.
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