The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants.
Aliases: ARF1GAP; HRIHFB2281
Entrez GeneID : 55738
Swissprot : Q8N6T3
WB Predicted band size : 44.7kDa
Host/Isotype : Mouse IgG2b
Species Reactivity : Human,Mouse
Immunogen : Purified recombinant fragment of human ARFGAP1 (AA: 270-414) expressed in E. Coli.
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